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  • Connect the symptoms of XLH

    Connect the symptoms.
    Is it XLH?

    Connect the symptoms of XLH
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    Understand how to manage XLH

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    Explore resources for you and your patients

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XLH is rare1

X-linked hypophosphatemia (XLH) is a lifelong, primarily hereditary disease characterized by chronic hypophosphatemia due to increased fibroblast growth factor 23 (FGF23) activity2,3

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XLH is primarily an inherited condition, which means it runs in families.3

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New symptoms of XLH may appear as patients get older and can worsen or change over time.4

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Individuals with XLH can continue to experience symptoms throughout their lives.4

Take action to help your patients

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Suspect XLH?

Connect their symptoms and accurately diagnose with the right tests.

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Manage XLH

Manage XLH early to prevent progressive bone damage.

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XLH resources and community

From case studies to brochures, find resources for you and your patients to understand more about this rare condition.

Stay connected

Set up time with a representative to talk more about XLH, or sign up for news and information about XLH.


1. Giannini S, Bianchi ML, Rendina D, Massoletti P, Lazzerini D, Brandi ML. Burden of disease and clinical targets in adult patients with X-linked hypophosphatemia. A comprehensive review. Osteoporos Int. 2021;32(10):1937-1949. doi:10.1007/s00198-021-05997-1 2. Carpenter TO, Imel EA, Holm IA, Jan de Beur SM, Insogna KL. A clinician's guide to X-linked hypophosphatemia. J Bone Miner Res. 2011;26(7):1381-1388. doi:10.1002/jbmr.340 3. Ruppe MD. X-linked hypophosphatemia. In: Adam MP, Everman DB, Mirzaa GM, et al., eds. GeneReviews®. Seattle (WA): University of Washington, Seattle; February 9, 2012. Updated April 13, 2017. 4. Skrinar A, Dvorak-Ewell M, Evins A, et al. The lifelong impact of X-linked hypophosphatemia: results from a burden of disease survey. J Endocr Soc. 2019;3(7):1321-1334. doi:10.1210/js.2018-00365